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Current evidence is not sufficient to support clinical use beyond research or investigational settings

To test whether SIRT3-mediated amelioration of HSC response to aging contributes to systemic benefits, bone marrow from Mx1-T3 or Mx1-Cre control mice was transplanted into lethally irradiated young wild-type (WT) recipient mice to allow HSCs overexpressing SIRT3 and control HSCs to repopulate the hematopoietic system of WT recipient mice

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