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In addition, in 1943, Leo Kanner established the term autism in a paper in which he reported and described 11 children who shared significant behavioral characteristics [4]

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The main phenotype of loss-of-function mutations in arGSTs is the decreased content of anthocyanins ( 1 ) 19,20,21,22,23,24,25,26,27,28 and proanthocyanidins 27 , which can be well explained by an incomplete biosynthesis due to the absence of an essential enzyme