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We considered the possibility that diminished ER stress, improved ER ultrastructure, and delayed protein maturation and secretion might together be explained by more stringent ER quality control

Agents 56:106054

Therefore, in addition to the bioactivation of T4 to T3, D1 also catalyzes the degradation of thyroid hormone

Using random forest regression as the predictive model, we identified pathways commonly associated with NRF2, such as reactive oxygen species (ROS) and xenobiotic metabolism, in addition to reduced glutathione and NADP levels, as top features associated with NRF2 dependency (Fig