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In the senescent state, FOXO4 accumulates in PML (promyelocytic leukemia) nuclear bodies where it binds and sequesters p53, preventing p53 from activating the mitochondrial apoptotic pathway

SticklerMMReddyAXiongJMHintonPRDuBridgeRHardingFA.The human G1m1 allotype associates with CD4+ T-cell responsiveness to a highly conserved IgG1 constant region peptide and confers an asparaginyl endopeptidase cleavage site