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Using the live-cell imaging of the green fluorescent protein (GFP)-based reporter models for Nrf2 and NF-B signaling, the researchers found that treatment with carbamazepine could cause DILI through an interconnected network of temporal changes in Nrf2 and NF-kB signaling, which influence each other and bring about phenotypes (slightly higher cell death) (Herpers et al., 2016)

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