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The type 2 allostasis is usually observed in psychosocial stress, pregnancy, obesity associated with metabolic syndrome, adaptation to cold and post-traumatic stress disease

However, the relationship between the number of OR and the cellular response is not linear

doi: 10.1007/s12015-021-10198-8

In this sense, mathematical models revealed that a second enzymatic activity might have been implemented in vertebrate organisms in order to prevent NAM accumulation [39]