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One could speculate that the deletion of key autophagy genes could indirectly lead to changes in mitochondria, for example, via increased mitochondrial biogenesis or preferential survival of cells that retain mitochondria and may not directly stem from deleterious degradation

Glutathione and vitamin C are a logical supplement pairing based on their ability to work together to neutralize free radicals, combat oxidative stress and support a healthy inflammatory responselike "couple goals" for antioxidant supplementation

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Second, tissue-specific regulatory mechanisms remain insufficiently understood