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Similarly, certain anticonvulsants, particularly phenytoin and phenobarbital, may alter B12 metabolism and could theoretically affect the therapeutic response to methylcobalamin supplementation

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Collectively, these changes translate into a more pronounced improvement in mucosal barrier repair than that achieved with 5-ASA alone ( The combination of natural bioactive compounds with 5-ASA offers a novel therapeutic strategy for ulcerative colitis through a stage-specific, multi-target synergistic approach.These complementary mechanismsspanning acute immunomodulation, antioxidative damage, followed by active mucosal repair, and microbiota-metabolic regulationare visually integrated in Figure 2, which provides a comprehensive overview of their temporally coordinated actions

Zhou J, Johnson JE, Ghetie V, Ober RJ, Ward ES