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One of our recent studies demonstrated that the most common GABA A R-1 positive cells are inhibitor cells (Golgi, vertical and cartwheel cells) although all eight types of DCN cells could be GABA A R-1 positive 38

GeneTher.5: 595 601

Notably, administration of NNMT inhibitors did not impact total food intake nor produce any observable adverse effects

We used hyperinsulinemic-euglycemic clamp, comprehensive phenotyping, global metabolomics and transcriptomics to investigate the metabolic impacts of hepatic CRL3 loss-of-function and the underlying mechanisms