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Endocr Rev 23 : 824854 Monzavi R and Cohen P (2002) IGFs and IGFBPs: role in health and disease

By the same time, the FDA approved the use of a equimolar combination of IGF-1 and IGFBP-3 (Mecasermin Rinfabate, iPlex), suggesting that it would be a better choice, seeming as it will require lower doses because of the augmented half-life of the molecule and buffering effect on concentration

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In the absence of impaired kidney function, an elevated MMA level in conjunction with elevated homocysteine suggests either a vitamin B 12 deficiency or a combined vitamin B 12 and folate deficiency (32)