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A more recent paper combined the use of cryo-EM and mass spectrometry on a recombinant AR protein that was bound to a canonical ARE [97]

Multiple metabolic pathways associated with glutamine, such as glutamine-mTOR signaling, glutamine-glutamate-other amino acid pathway, glutamine-ISR stress pathway, and glutamine-autophagy pathway, have been observed to modulate the differentiation of Th17 and Tregs [136]

This sophisticated interplay of elesclomol-Cu and 4-OI has demonstrated successful tumor growth reduction in both in vitro and in vivo environments (162)