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This is a very important and possibly crucial biochemical mechanism, since reversible thiolation of proteins can modify their enzymatic activities (glycolytic enzymes, components of the respiratory chain, creatine kinase, carbonic anhydrase), ion and metabolite transport, gene transcription, signal transduction and cell death

Previous ischemia and reperfusion injury results in resistance of the kidney against subsequent ischemia and reperfusion insult in mice

Combined strategies involving controlled mechanical loading (exercise) followed by rest, along with glutathione optimization, have been associated with improved redox balance in joint tissues in animal models

& Jeon, S