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This B12-IF complex reaches the terminal ileum, where it binds to heterodimeric receptors cubam composed of an outer protein cubulin and transmembrane protein amnionless , located on the surface of polarized epithelial enterocytes in the apical brush border ( In the bloodstream, free B12 may be bound by HC or transcobalamin (TC)

Another commenter that supported the proposal encouraged CMS to add language to the regulations that would prevent accreditors from engaging in word play as a means of circumventing the proposed policy