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Large randomized trials with Rimonabant have demonstrated efficacy in treatment of overweight and obese individuals with weight loss significantly greater than a reduced calorie diet alone

Nutrients, 14 (14), 2831

IGF-IEc expression, regulation and biological function in different tissues

Knockdown of PPT1 (Supplemental Figure 8A), or treatment with high concentrations of HCQ (Supplemental Figure 8B) also induced LMP that could be reversed by NAC, whereas chemical inhibition of ULK1 did not induce LMP (Supplemental Figure 8C)