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362 Considering the expression of the GLP-1R in thyroid C cells and the ability of GLP-1 to stimulate calcitonin secretion through a cAMP-mediated mechanism in vitro, it is plausible that calcitonin plays a role in the alterations in bone metabolism observed in GLP-1R-treated animals

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Regardless of these observed effects, more research is needed to determine whether radio-protective interventions would offer long-term benefit or decreases in toxicity in clinically relevant populations