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If conjugation of HMCDs with anti-neoplastic agents increases the intracellular drug concentration, it is likely the conjugate will bind to different, or additional drug targets, increasing the potency relative to the unconjugated drug

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Inhibition of DRP1 expressions or activity has been shown to significantly suppress tumor cell proliferation, invasion, and migration, while enhancing apoptosis and increasing synergistic responses to chemotherapy and radiotherapy [47, 48]

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