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Clinicialtrials.gov (2020)

Suren GargSKushwahaKDubeyRGuptaJ

Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances ( MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)

PMID: 40744390 Eur J Pharmacol Mechanism of berbamine-mediated DNA damage in synovial fibroblasts to alleviate rheumatoid arthritis