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Description

DNA ligase IV, which plays a vital role in non-homologous end joining (NHEJ), can use NAD+ to get AMP moiety for DNA end ligation

The MDSC and neutrophils create arginase, which depletes arginine from the TME

An increase in the flow of Ca 2+ is necessary for signal transduction, the formation of immune synapses, and the implementation of specific cytotoxicity of CD8 + T cells, which involves the costimulatory molecule of the cell surface LFA-1 and Mg 2+ (129)