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Key GPX1 Variants rs1050450 (Pro198Leu) Leu allele carriers: Reduced GPX1 activity, increased oxidative stress

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69 According to this hypothesis, the progression of NAFLD-associated liver toxicity and inflammation is accomplished through multiple mechanisms, which include insulin resistance, nutritional factors, gut microbiota, genetic and epigenetic alterations, adipocyte-specific secretion of steroid hormones, cytokine prostaglandins, fatty acids, and cholesterol

Repeated injections are not viable in the clinic, necessitating the development of improved delivery methods with high tissue intake, biosafety, and simplicity of application (Wang et al., 2022b)