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To cope with oxidative stress, arthropods evolve antioxidant enzymes for removing excess ROS to maintain intracellular redox homeostasis and avoid oxidative damage

As a sensitive indicator, any variation of the optimal intracellular ratios of GSH to GSSG can result in human diseases such as cancer, cardiac disease, apoplexy and many neurological disorders 10,11,12,13,14,15

1 Environmental or metabolic stressors, including nutritional state, physical activity, hormonal regulation, and pathological conditions such as heart failure, cancer cachexia, and chronic liver disease, require appropriate fuel selection to maintain metabolic homeostasis