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Within each fold, models were fitted on four subsets and evaluated on the held-out subset, yielding mean metrics across folds: Accuracy (fraction correctly classified), AUROC, AUPRC, Specificity (true negative rate), Precision(proportion of positive predictions that are correct), and Recall (proportion of actual positives that are correctly identified)

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Eleven studies contained some concerns about the risk of bias

Accutane is the former prescription drug brand name for isotretinoin, a vitamin A derivative often used to treat severe acne (isotretinoin is now sold under the generic names Zenatane, Absorica, Myorisan, Claravis, and Amnesteem instead)