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Global cerebral ischemia from cardiac arrest during the light (inactive) phase impaired survival and exacerbated outcome characterized by increased microglial activation, degenerating neurons, and proinflammatory cytokines in the hippocampus compared to dark (active) phase in C3H mice (Weil et al., 2009)

This research indicates dietary intake of iron does not proliferate PD risk (56) giving more credibility to environmental pathways as vectors of susceptibility

As previously mentioned, proof-of-concept came in 2008, when intra-ovarian BM-MSC transplantation in cyclophosphamide-injured rats restored estrous cycling, increased estrogen production and rebuilt follicular architecture, establishing that paracrine support from these cells can revive a depleted ovary [167]

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