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Iron overload, however, significantly reduces Bifidobacterium abundance, a disturbance potentially linked to gut microbiota dysbiosis mediated by intestinal ferroptosis

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436 A recent meta-analysis of 43 randomized controlled trials involving adult subjects with acupuncture for MDD demonstrated that acupuncture, either alone or in combination with antidepressants, significantly reduced the hamilton depression scal scores and had fewer adverse effects compared to antidepressants, however, further rigorous experiments are still required to determine the optimal frequency of acupuncture for MDD in order to achieve better efficacy