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Thioredoxin peroxidase, a selenium-dependent enzyme, also has an important role in the elimination of hydrogen peroxide (Lu and Holmgren, Figure 7 Recently, hydrogen peroxide has been shown to use water channels, the aquaporins, to cross the lipid membrane more rapidly than diffusion allows (Bienert et al., 1995b)

(Given the potential long-term consequences of NMOSD relapses, the company could not ethically include a direct placebo arm in its Phase III trial.) Ultomiris was well-tolerated overall, and most treatment-emergent events were mild or moderate in severity, according to AstraZeneca

doi: 10.1016/J.HAZADV.2022.100094 64

Keshavan), R24 GM078233 (Rima Kaddurah-Daouk), c UL1 RR024153 and NIH/NCRR/GCRC Grant M01 RR00056], Metabolomics Research Network (Rima Kaddurah-Daouk)