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10.1016/j.jep.2023.116289 180 WuY.LiuL.ZhaoY.LiX.HuJ.LiH.et al (2024b)

In RA pathogenesis, activated RA fibroblast-like synoviocytes (RA-FLSs) exhibit proliferative features similar to tumor cells and subsequently cause cartilage erosion, which will eventually lead to joint destruction (1, 2)

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Over time, this cellular protection can translate into improved physical stamina, a higher threshold for exertion, and a reduction in the severity of post-exertional crashes