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Nave age and sex matched mice were initially used to determine the optimal shock value

Overwhelming scientific evidence in its favor is why FDA has approved PT 141

195,196,197 At the cellular level, this translates into a massive increase in cytoplasmic Na + concentration, membrane depolarisation and opening of voltage-gated Ca 2+ channels, which in turn promotes massive release of glutamate that results in even large depolarisation enlarging Na + and Ca 2+ influx thus completing the vicious circle of excitotoxic damage, as Ca 2+ overload triggers necrotic cell death

BPC-157 may accelerate the healing that physical therapy supports, but the therapeutic exercise itself remains essential for optimal outcomes