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another advantage of an on-line DAD detector is the possibility of detection of poorly ionizing compounds that cannot be detected by an MS detector, and simultaneous quantitative and qualitative analysis when the MS detector works in dynamic range modewhich results in reduction of time and cost of analysis), and a high-resolution mass spectrometer (Q-TOF, Orbitrap), especially MS/MS enabling ion fragmentation

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Notably, this reduction in systemic LPS was accompanied by a down-regulation of pro-inflammatory mediators (e.g., TLR4, NF-B, and IL-6) in the uterus, suggesting that butyrate can alleviate high-grain induced inflammation across the gut-uterus axis by fortifying the epithelial barrier 166

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