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The GPX4-mediated antioxidant system can reduce the peroxide concentration, which may affect LOX activity, reducing the peroxidation rate of PUFAs and ultimately inhibiting ferroptosis (63)

While its actual cause is still unknown, one of the biggest factors in its development is believed to be oxidative stress

And typically when we're talking about angiogenesis in the context of tissue rejuvenation and repair, we're talking about the addition of new capillaries and or blood vessels