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Autoimmune thyroid disorders Hashimotos thyroiditis Hashimoto thyroiditis is the most common cause of hypothyroidism in iodine-sufficient areas, and it is caused by thyroid gland destruction due to autoimmune disturbance, where the thyroid follicular cells are subjected to death by the effect of CD8 + T cells

Cases of rare, severe hepatic reactions, including liver necrosis, jaundice, fulminant hepatitis (with and without jaundice), and liver failure, some of which resulted in fatalities or liver transplantation, have been reported with diclofenac use

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How NSAIDs May Increase Free Radical Production NSAIDs work by inhibiting cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2, which play a role in inflammation and pain signaling