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[PubMed] [Google Scholar] 366.Lu X., Zhang Q., Xu L., Lin X., Fu J., Wang X., Liu Y., Lin Y., Li B., Wang R., et al

ACE 2 is a transmembrane protein that contains an extracellular zinc binding domain and located at multiple sites like renal tubular epithelium, lung alveolar epithelial cells, arterial and venous endothelial cells etc 20,54,55

This robust upregulation and stabilization of HIF-1 ultimately drives the transcription of VEGF, dramatically stimulating endothelial cell proliferation and tumor angiogenesis