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Function of the GSTP1-G6PD-SRC complex as a metabolic signalosome Our work implies that GSTP1 plays a dominant role linking G6PD and SRC to form a signalosome that provides a basis, under metabolic stresses, for robust cancer cell proliferation upon lactic acid signaling, which could regulate many aspects of cellular metabolism

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Because TB-500 builds up a systemic presence, a 4-week cycle ensures that the subject does not reach an over-saturated level where the actin-sequestering effect becomes counterproductive