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Description

As a key energy substrate for tumor cells, Gln can be catabolized by glutaminase to generate -ketoglutarate (-KG), which directly enters the tricarboxylic acid (TCA) cycle [1]

The metabolites are then conjugated and excreted whether in feces or urine [156, 157]

In the following sections, we will discuss the nephroprotective effects and the underlying protective mechanisms of ALA in a variety of animal models of kidney injury, as indicated in Figure 1