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They are used in walking, running and many other physical activities

During ERS, the three major UPR pathways regulate autophagy (Figure 3) in different ways (167)

This ability determines the important roles assigned to persulfides in the biosynthesis of sulfur-containing cofactors, such as iron-sulfur clusters

One research group proposed that ROS are a signal generated by ER stress and UPR activation, consistent with their observation that antioxidant treatment reduces oxidative stress and UPR activation [41]