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Description

A proteins hydrodynamic volume is a key structural feature that changes significantly when the globular protein denatures and unfolds (Tanford, 1968

In the case of chronic myeloid leukemia (CML), for example, chromosomal translocation t(9;22)(q34;q11) is the leukemia-driving event, which generates the fusion between BCR and ABL genes, and the resultant Bcr-Abl kinase allows cells to survive and proliferate in a growth factor-independent manner 2,3