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doi: 10.1016/j.phrs.2012.09.004 342 MoraisJBSDiasTMSCardosoBEPde Paiva SousaMSousaTGVArajoDSCet al

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death

At the same time, it also expands and becomes more porous

The systemic impact of age-related AT dysfunction extends beyond local effects, contributing to widespread metabolic dysfunction and chronic low-grade inflammation (401)