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The risk is therefore heightened, just as it is when two types of SSRIs are taken together

8-hours (snack: coffee or tea (one cup: 75 mL), biscuit (50 g) and water (150 mL))

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In the case of difloxacin, the highest degradation rate was observed at neutral pH (close to its isoelectric point), but sarafloxacin was least stable at pH = 9 (Prabhakaran et al