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In diabetic nephropathy, up-regulated CD36 promotes free fatty acid (FFA) uptake, whereas down-regulated ABCA1 hinders extracellular transport of phospholipids and cholesterol

When astrocytes take up glutamate, not only is there post-synaptic attenuation of nearby neurons, but within the astrocyte there is a switch from oxidative metabolism to aerobic glycolysis, and glucose is diverted from the TCA cycle to glycolysis and greater lactate production

Peripheral inflammatory signals can gain access to the CNS through several pathways, as follows: (1) several brain areas are not covered by the bloodbrain barrier (BBB)

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