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2 Diuretics: brief historic perspectives 2.1 Thiazides and thiazide-like diuretics Hydrochlorothiazide and chlorthalidone, a benzothiadiazide and a thiazide-like diuretic, respectively were introduced during 1957-59 and the former quickly became a mainstay in the treatment of hypertension

General measures in gout Although lifestyle changes rarely result in adequate reduction in plasma urate without medication, the following are recommended

Although TAM itself can be toxic, we observed a rather low mortality rate of 3.7% with a TAM concentration of 100 mg/kg, tested in many adolescent and adult mice (older than 21 days, n = 4,080)

Sulfide:quinone oxidoreductase alleviates ferroptosis in acute kidney injury via ameliorating mitochondrial dysfunction of renal tubular epithelial cells