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The accumulation of visceral adipose tissue tends to suppress adiponectin levels, resulting in insulin resistance, vascular dysfunction, and systemic inflammation

Future research should further clarify the specific roles of HO-1 in different cell types and pathological conditions, and combine clinical studies to assess its therapeutic value in atherosclerosis

It should be noted that glutamate derived from glutamine may also undergo transamination reactions (Figure 3), which could lead to overestimations of glutamine oxidation when only assessing metabolic connections between amino acids