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Large IOP increases induce ischemia, which compromises the diffusion of glucose, oxygen and lactate through capillary compression, however, even small (3-5 mm Hg) elevations in IOP may result in hypoxia, accumulation of reactive oxygen species and hypoxia-induced factors (e.g., HIF-1 and HIF-2), downregulation of astroglial glutathione content and induction of the autophagosome (117)

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Prolonged exposure of Caco-2 and SK-CO15 human intestinal epithelial monolayers to ethanol reduced JAM-A protein expression by 70%

HSAs offer long-term growth potential, but only if contributions are saved and invested rather than spent on frequent medical reimbursements