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This effect is probably mediated by the MAPK/Erk1/2 pathway, whereby insulin stimulates the hypothalamus to secrete gonadotropin-releasing hormone (GnRH) ( 3.3 Advanced glycation end products AGEs can severely impair sperm function through multiple mechanisms

To induce colitis, all groups except the NC group received 3.0% (w/v) dextran sulfate sodium (DSS) dissolved in sterile drinking water ad libitum for 7 days, while the NC group received sterile drinking water only