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Biophysical Journal

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Chen T., Zhang Z., Weng D., Lu L., Wang X., Xing M., Qiu H., Zhao M., Shen L., Zhou Y., Chang J., Li H.-P

Selective clearance of glycoforms of a complex glycoprotein pharmaceutical caused by terminal N-acetylglucosamine is similar in humans and cynomolgus monkeys

On the other hand, low portal insulin levels (e.g., during prolonged fasting) reduce hepatic GHR expression, thereby reducing IGF-1 levels and increasing GH concentrations by the lack of IGF-1 feedback on pituitary GH secretion (Fig