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61 Concurrently, persistent activation of the sterol regulatory element-binding protein 1c (SREBP-1c) pathway in hepatocytes promotes de novo lipogenesis, further increasing lipid deposition

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doi: 10.1021/jf402146s

The direct contact of alcohol with the mucosal lining of the upper GI tract induces numerous metabolic and functional alterations, which may lead to a broad spectrum of acute and chronic ailments