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The interplay between T cells and dendritic cells is promoted by pdpn-expressing fibroblastic reticular cells in conjunction with pdpn + stromal fibroblasts, facilitating the transition from innate to adaptive immunity within TLS (38, 142, 143)

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2B), probably due to a slight increase in the GAPDH protein level (Fig

These include using biodegradable backbones or enzymatically cleavable linkers, surface neutralization (for example hydroxylation, carboxylation or PEGylation) to reduce cationic surface reactivity, minimizing generation/size for dendrimers while preserving targeting, and requiring chronic-dosing safety packages that measure persistent microglial activation and behavioral outcomes before first-in-human trials