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Interestingly, differences in prooxidative parameters were more profound in acute coronary syndrome patients compared with coronary artery disease patients indicating that the acute form of coronary artery disease is more susceptible to oxidative damage, suggesting that use of antioxidant therapy may be warranted to reduce oxidative stress in this disorder (154)

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Therefore, we refer to them as putative novel loci that occur adjacent to previously identified association signals and require replication to determine whether they represent independent effects or extensions of known loci

Pharmacological effects of exogenous NAD on mitochondrial bioenergetics, DNA repair, and apoptosis