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Therefore, CDK5-triggered degradation of cytoplasmic EZH2 may also have little effect

In contrast, cancer-type-specific adaptive strategies, such as driver mutation dependence, microenvironmental stress adaptation, and epigenetic dysregulation, necessitate the development of tailored therapeutic regimens

5.1.2.2 NF-B Nuclear factor-B (NF-B) is a nuclear factor family consisting of multiple transcription factors involved in regulating inflammatory response, cell proliferation, tumor development, and invasion

Specifically, they reported that higher levels of HO-1 expression correlate with an increase in TFR expression and a decrease in SLC40A1 expression, ultimately leading to iron accumulation (245)