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The patients were randomized into four groups: three received different doses of tirzepatide 5, 10, and 15mg per week and the fourth received 1mg semaglutide

It is noteworthy that acute toxicity varies depending on species, size, biological variables, and chemical formulations 32

All patients benefit from lifestyle management and optimisation of acute treatment, whereas patients with four or more migraine days a month or attacks that are difficult to control may benefit from preventive treatment

The activation of PI3K/AKT signaling, downstream from the insulin/IGF-1 receptors, stimulates the activity of mTOR which in turn is a potent inhibitor of autophagy (Fig