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Research has indicated that ATO augments ROS production via Trx inhibition and NOX activation, displaying encouraging results in treatment of relapsed APL [225, 226]

Melanin, the pigment responsible for hair color, is formed by pigment cells named melanocytes within the follicles

Inhibiting CYP1B1 in combination with PD-1 antibodies greatly improves the immune response to tumors [287]

Manczak M, Mao P, Calkins MJ, Cornea A, Reddy AP, Murphy MP, Szeto HH, Park B, Reddy PH (2010) Mitochondria-targeted antioxidants protect against amyloid- toxicity in Alzheimers disease neurons