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3.2 MTHFD2 MTHFD2, traditionally recognized for its enzymatic roles in folate metabolism, has recently emerged as a multifaceted regulator with crucial non-enzymatic functions, including the regulation of DNA damage repair, cell cycle progression, RNA metabolism, and RNA methylation (Fig

In particular, CP-treated WT showed significant upregulation of 30 defense genes, including genes encoding the disease resistance protein RGA2, MLO-like protein OsMLO8, calmodulin-binding protein 60b isoform, NB-LRR protein Xa38, defensin-like DEFL protein DEFL78, and LRR receptor-like kinase, none of which were upregulated in CP-treated osvirk1 (Fig