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LDL r-null mice fed a choline-supplemented chow diet exhibit aggravated aortic aneurysm pathogenesis in a gut microbiota-dependent manner mediated by the generation of TMAO [66]

medRxiv 2026, IQVIA PharMetrics cohort (n=20,504 non-diabetic weight-loss users), incident allodynia 35 vs 15 per 1,000 person-years against bupropion-naltrexone, adjusted HR 2.15 (95% CI 1.572.96)